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A world-first discovery, published in the journal Science, rewrites our understanding of how cells control the production of DNA’s building blocks - and how this process affects the response to widely used cancer and autoimmune drugs.The study, led by researchers from the University of Oxford in collaboration with scientists from the CeMM (Research Centre for Molecular Medicine), Austria focused on the enzyme NUDT5, known to have a role in cellular…

Nations and companies have made ambitious climate pledges, but to prevent catastrophic climate change what matters is concrete, implemented, enforceable rules. That's what we're surveying.Co-lead Professor Thomas Hale, Blavatnik School of GovernmentThe granular survey of 37 major countries’ climate-related laws and regulations, compiled by Oxford University researchers and dozens of leading global law firms, gives the most detailed view yet of how climate policy is developing at a time of unprecedented…

Ricardo Rocha with a Príncipe Green Snake (Hapsidophrys principis), endemic to Principe Island. Photo credit: Patricia Guedes. Although islands make up less than 7% of the Earth’s surface, they harbour a disproportionate share of the planet’s biodiversity. Out of the roughly 12,000 known reptile species, around one-third are confined to islands - including iconic species such as the Galapagos tortoise and Komodo Dragon. These isolated ecosystems act as natural laboratories…

Using a new technique called MCC ultra, the team mapped the human genome down to a single base pair, unlocking how genes are controlled, or, how the body decides which genes to turn on or off at the right time, in the right cells. This breakthrough gives scientists a powerful new way to understand how genetic differences lead to disease and opens up fresh routes for drug discovery.‘For the first…

The global food system is under growing scrutiny for its environmental and health impacts. It contributes substantially to climate change, biodiversity loss, and diet-related disease, making its current trajectory unsustainable.  Rising public awareness of these costs is beginning to shift habits and policies alike: plant-based diets are gaining traction among consumers and governments seeking to address both climate and health imperatives.  Yet food systems are also social and economic lifelines,…

The Schmidt Sciences AI2050 programme funds researchers to pursue projects to help AI create immense benefits for humanity by 2050. Announced today, 28 academics will join the fourth cohort who will collectively receive more than $18 million in AI2050 fellowships.‘AI is underhyped, especially when it comes to its potential to benefit humanity,’ said Eric Schmidt, co-founder of Schmidt Sciences with his wife Wendy. ‘The AI2050 fellowship was established to turn that potential…

Dennis J. Snower. Credit: Global Solutions Initiative The world is edging toward a financial storm with few safe harbours in sight. What began as warnings about “the end of America’s exorbitant privilege” has become front-page news.The dollar’s dominance - long seen as unassailable - is now under real strain as global investors, central banks, and even US allies start hedging against a post-dollar world.In Washington, President Trump’s second term has…

Blazars are active galaxies powered by supermassive black holes that launch narrow, near-light-speed beams of particles and radiation towards Earth. These jets produce intense gamma-ray emission extending up to several teraelectronvolts (1 TeV = 1012/a trillion eV), which is detected by ground-based telescopes. As these TeV gamma rays propagate across intergalactic space, they scatter off the dim background light from stars, creating cascades of electron–positron pairs. The pairs should then…

The company was founded in December 2008 by engineering Professor Constantin Coussios OBE FREng FMedSci and transplant surgeon Professor Peter Friend FMedSci through Oxford’s Institute of Biomedical Engineering and the Nuffield Department of Surgical Sciences.The acquisition marks the first exit under the pioneering partnership between the Department of Engineering Science and Technikos that led to the creation of the Institute of Biomedical Engineering (IBME). Technikos, a specialist medical technology venture…